Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells
نویسندگان
چکیده
منابع مشابه
Human umbilical mesenchymal stem cells promote recovery after ischemic stroke.
BACKGROUND AND PURPOSE Stroke is a cerebrovascular defect that leads to many adverse neurological complications. Current pharmacological treatments for stroke remain unclear in their effectiveness, whereas stem cell transplantation shows considerable promise. Previously, we have shown that human umbilical mesenchymal stem cells (HUMSCs) can differentiate into neurons in neuronal-conditioned med...
متن کاملAntenatal factors associated with perinatal arterial ischemic stroke.
BACKGROUND AND PURPOSE Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. METHODS A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2...
متن کاملMesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model
Numerous studies have reported that mesenchymal stem cells (MSCs) can ameliorate neurological deficits in ischemic stroke models. Among the various hypotheses that have been suggested to explain the therapeutic mechanism underlying these observations, neurogenesis is thought to be critical. To enhance the therapeutic benefits of human bone marrow-derived MSCs (hBM-MSCs), we efficiently modified...
متن کاملTrophic factors and stem cells for promoting recovery in stroke.
BACKGROUND Stem cell therapy for stroke is in its initial stages as an option to restore lost neurological functions after stroke. OBJECTIVE To provide a comprehensive review of studies involving stem cells in stroke treatment and to highlight new evidence from the ongoing clinical trials. METHODOLOGY We performed a systematic study of various published journals in online medical libraries ...
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Stem cell-based therapy seems to be a promising strategy to treat neurodegenerative diseases, in particular those that are fatal and difficult to treat. However, the sources of stem cells are required to comply with the requirement of availability and expanding in culture, to overcome ethical objections and concerns of graft rejection. Mesenchymal stem cells (MSCs) are population of adult stem ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2017
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2017.243